81377  München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Prof. Haass started to work on Alzheimer's disease (AD) in 1990 at a time, when very little was known about the cellular mechanisms involved.  Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß.  Christian Haass hypothesized against the widely accepted general opinion hinein this field that Aß may Beryllium produced from its precursor rein a physiologically üblich pathway and not necessarily hinein a pathological process.  Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions.  This pivotal finding was a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved hinein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production hinein patients.

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You want to get your driving licence in Munich as soon as possible, rein an enjoyable and straightforward way? If so, you’ve come to exactly the right place! We are a Munich driving school and guarantee you all-round support rein theory, practice and other aspects of Fortbildung.

Yes, you can, but the Fortbildung contract only becomes valid when it is signed by your father or mother.

The practical side is taken care of rein our top-notch driving-school vehicles, each equipped with a double-pedal Organisation. If requested, we can also provide you with tuition rein an automatic car at our driving school rein Munich.

As our driving instructors receive ongoing further Weiterbildung, they are hinein a position to inform you on all the latest road traffic requirements. For easier comprehension during practical training, we have instructors that speak not only German but also English, Persian and Greek.

Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects.  Christian Haass was the first to demonstrate a physiological function for beta-secretase.  He showed that this protease is critically Hier required for the regulation of myelination.  Furthermore, he identified a novel APP processing pathway, which welches overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors.  He was also the first to identify the highly complicated subunit composition of gamma-secretase.  All these findings not only helped to understand several signaling pathways critically involved hinein brain development (such as myelination and cell differentiation) but also provided the Stützpunkt for several current therapeutic approaches.

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We will give you driving lessons designed to suit your own particular needs not only during the week but also on Saturdays. Rein this way you will get your driving licence as quickly as possible.

einer elektrischen Antriebsmaschine oder einem Verbrennungsmotor mit einem Hubraum von nicht mehr als 50 cm³ oder

We are the new, modern Munich driving school for Schwabing and Maxvorstadt. On three evenings a week, ur fully-equipped driving school will give you the opportunity to become familiar with the theory – quickly and thoroughly.

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At the earliest, approx. 3 – 5 months before your 18th birthday, depending on whether you wish to do the theoretical and the practical Schulung one after the other or at the same time.

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